Ethanol, 1-ethoxy-2,2,2-trifluoro- → 4-chloro-N-(2,2,2-trifluoro-1-hydroxyethyl)benzamide

HRID 479474

Reaction equation

HRID 479474 reaction equation
C(O[CH:4]([OH:9])[C:5]([F:8])([F:7])[F:6])C.[Cl:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([NH2:17])=[O:16])=[CH:13][CH:12]=1>>[Cl:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([NH:17][CH:4]([OH:9])[C:5]([F:6])([F:7])[F:8])=[O:16])=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 9897Ethanol, 1-ethoxy-2,2,2-trifluoro-HCID 120844-Chlorobenzamide

Product 1

HCID 113227584-chloro-N-(2,2,2-trifluoro-1-hydroxyethyl)benzamide

Procedure

Trifluoroacetaldehyde ethyl hemiacetal and 4-chlorobenzamide were processed as described in Example 1 A to provide the desired product.

Sources & evidence

ORD record
ord-a2922543269140889f4ca098a8885dc4
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Linked notes

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