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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 480Generated: October 24, 2026

1,4-Dioxa-8-azaspiro(4.5)decane → 8-(6-Methoxy-2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane

https://huagongshe.com/en/reaction/480

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxa-8-azaspiro(4.5)decaneHCID 67435—
Reactant2-Bromo-6-methoxypyridineHCID 256810—
ReagentSodium t-butoxideHCID 23676156—
CatalystPalladium (II) acetateHCID 4144353—
Catalyst2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 11155794—
Product8-(6-Methoxy-2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decaneHCID 8158114669.11%

Reaction Steps

The same procedure as EN03653-93-01.

Provenance & Evidence

Source dataset750 AstraZeneca ELN dataset
ORD IDord-74d98b785957480d946a0d3ab89bccf5
Source note750 AstraZeneca ELN dataset