Methyl iodide → 4-(3-Acetylphenyl)amino-2-amino-1,6-dimethylpyrimidinium iodide

HRID 480413Notes

Reaction equation

HRID 480413 reaction equation
[CH3:1][C:2]1[N+:7]([CH3:8])=[C:6]([NH2:9])[N:5]=[C:4]([NH:10][C:11]2[CH:16]=[C:15]([C:17]([CH3:19])=[O:18])[CH:14]=[CH:13][CH:12]=2)[CH:3]=1.C(C1C=C(NC2C=C(C)N=C(N)N=2)C=CC=1)(=O)C.C[I:39]>CC(C)=O>[I-:39].[C:17]([C:15]1[CH:16]=[C:11]([NH:10][C:4]2[CH:3]=[C:2]([CH3:1])[N+:7]([CH3:8])=[C:6]([NH2:9])[N:5]=2)[CH:12]=[CH:13][CH:14]=1)(=[O:18])[CH3:19]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 133110Cni H1594HCID 4630112-Amino-4-(3-acetylphenyl)amino-1,6-dimethylpyrimidinium iodide

Product 1

HCID 120932594-(3-Acetylphenyl)amino-2-amino-1,6-dimethylpyrimidinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Compound No. 14 (CNI-H1494): 4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine, Compound No. 15, (0.968 g) was suspended in acetone (5 mL) containing methyl iodide (2 mL) was heated at reflux for 48 hr. Filtration after cooling gave 0.657 g of 4-(3-acetylphenyl)amino-2-amino-1,6-dimethylpyrimidinium iodide as a white powder, mp 238-40° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 48 hr
  3. filtrationFiltration
  4. temperatureafter cooling

Sources & evidence

ORD record
ord-9ce729e5b27944b59fd91ea4c5eeb15b
Source dataset
uspto-grants-2003_11
Patent number
US06649797B2

Reaction notes

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