Sulfuric Acid → Salbutamol

HRID 48093

Reaction equation

HRID 48093 reaction equation
S(=O)(=O)(O)O.[Cl-].[Na+].[CH3:8][C:9]([NH:12][CH2:13][CH:14]([OH:24])[C:15]1[CH:16]=[CH:17][C:18]([OH:23])=[C:19]([CH2:21][OH:22])[CH:20]=1)([CH3:11])[CH3:10].OS(O)(=O)=O>O>[CH3:11][C:9]([NH:12][CH2:13][CH:14]([OH:24])[C:15]1[CH:16]=[CH:17][C:18]([OH:23])=[C:19]([CH2:21][OH:22])[CH:20]=1)([CH3:8])[CH3:10]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 5234Sodium ChlorideHCID 9884233Salbutamol Sulfate

Product 1

HCID 2083Salbutamol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In an alternative embodiment, the inhalation solution of the present invention may be prepared as follows: (i) fitting a high density polyethylene (HDPE) or stainless steel formulation tank with a bottom drain and peristaltic recirculation system (for HDPE) or tri-blender (for stainless steel) for mixing; (ii) filling the tank with approximately 90% of the required amount of Purified Water USP at a temperature of between 18° C. to 25° C.; while mixing, (iii) adding sulfuric acid, Sodium Chloride USP, and at least a therapeutically effective pediatric amount of Albuterol Sulfate USP to the tank; (iv) continue mixing until all chemical components are dissolved; (v) adding Purified Water USP to adjust the final volume, if necessary, thus producing an albuterol mixture.

Workup

  1. customIn an alternative embodiment, the inhalation solution of the present invention may be prepared
  2. additionfor mixing
  3. customof between 18° C. to 25° C.
  4. additionwhile mixing
  5. dissolutionare dissolved
  6. customPurified Water USP

Sources & evidence

ORD record
ord-5e22ad9c5cce42a49be1bce2ca1f9a58
Source dataset
uspto-grants-2004_03
Patent number
US06702997B2

Linked notes

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