Chloroacetyl chloride → 2-Chloro-1-[4-(2-cyanophenyl)piperazin-1-yl]ethanone

HRID 481352

Reaction equation

HRID 481352 reaction equation
[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH2:7][CH2:6]1)=[O:4].ClCC(Cl)=O.C(C1C=CC=CC=1N1CCNCC1)#[N:24].C(=O)([O-])[O-].[Ca+2]>C(C(C)=O)C>[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]#[N:24])[CH2:7][CH2:6]1)=[O:4]

Participants

6

Reactant 4

HCID 6577Chloroacetyl chlorideHCID 10112Calcium CarbonateHCID 2735875N-(2-Cyanophenyl)piperazineHCID 47412122-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone

Product 1

HCID 104005542-Chloro-1-[4-(2-cyanophenyl)piperazin-1-yl]ethanone

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

Compound 17A is prepared according to the same procedure as that for 12A, using the following reactants: chloroacetyl chloride (670 μl, 8.4 mmol), 1-(2-cyanophenyl)piperazine (1.32 g, 7 mmol), calcium carbonate (2.1 g, 21 mmol), methyl ethyl ketone (30 ml).

Sources & evidence

ORD record
ord-ba90fcc583e242a0a902eaec2bc6b1ed
Source dataset
uspto-grants-1998_08
Patent number
US05789412

Linked notes

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