2-Cyclopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine → 1-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl-methyl)thiophen-2-yl]cyclopent-3-ene carboxylic acid ethyl ester

HRID 481393

Reaction equation

HRID 481393 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[N:8]([CH2:14][C:15]3[S:19][C:18]([C:20]4([C:25]([OH:27])=[O:26])[CH2:24][CH:23]=[CH:22][CH2:21]4)=[CH:17][CH:16]=3)[C:9]([CH2:11][CH2:12][CH3:13])=[N:10][C:5]2=[C:4]([CH3:28])[CH:3]=1.[CH:29]1(C2NC3C(N=2)=NC(C)=CC=3C)C[CH2:30]1>>[CH2:29]([O:26][C:25]([C:20]1([C:18]2[S:19][C:15]([CH2:14][N:8]3[C:6]4=[N:7][C:2]([CH3:1])=[CH:3][C:4]([CH3:28])=[C:5]4[N:10]=[C:9]3[CH:11]3[CH2:13][CH2:12]3)=[CH:16][CH:17]=2)[CH2:24][CH:23]=[CH:22][CH2:21]1)=[O:27])[CH3:30]

Participants

3

Reactant 2

HCID 103134402-Cyclopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridineHCID 54082332HCID 54082332, compound

Product 1

HCID 701025241-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl-methyl)thiophen-2-yl]cyclopent-3-ene carboxylic acid ethyl ester

Procedure

Alkylation was performed on (11) as described in Example 1, Step 5, using 2-cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridine (13) to obtain the title compound (12).

Sources & evidence

ORD record
ord-97aef10064124ab9838dfb897d7ba39e
Source dataset
uspto-grants-1998_08
Patent number
US05789415

Linked notes

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