(2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidine dihydrochloride → (2S,3S)-3-(5-(2-Cyano-1,1-dimethylethyl)-2-methoxybenzyl)amino-2-phenylpiperidine Dihydrochloride

HRID 481518

Reaction equation

HRID 481518 reaction equation
[C:1]([CH2:3][C:4]([C:7]1[CH:8]=[CH:9][C:10]([O:15][CH3:16])=[C:11]([CH:14]=1)[CH:12]=O)([CH3:6])[CH3:5])#[N:2].[ClH:17].Cl.[C:19]1([C@H:25]2[C@@H:30]([NH2:31])[CH2:29][CH2:28][CH2:27][NH:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.Cl.Cl.C(C1(C2C=CC(OC)=C(C=2)CN[C@H]2CCCN[C@H]2C2C=CC=CC=2)CC1)#N>>[ClH:17].[ClH:17].[C:1]([CH2:3][C:4]([C:7]1[CH:8]=[CH:9][C:10]([O:15][CH3:16])=[C:11]([CH:14]=1)[CH2:12][NH:31][C@H:30]1[CH2:29][CH2:28][CH2:27][NH:26][C@H:25]1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([CH3:6])[CH3:5])#[N:2]

Participants

4

Procedure

This compound was prepared from Compound 47 and Compound 3 in the same manner of Compound 5.

Sources & evidence

ORD record
ord-be775788e7894e2e97a2cf6051906a9d
Source dataset
uspto-grants-1998_08
Patent number
US05789423

Linked notes

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