(2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidine dihydrochloride → (2S,3S)-3-(5-(1-Cyanocyclohexyl)-2-methoxybenzyl)amino-2-phenylpiperidine Dihydrochloride

HRID 481520

Reaction equation

HRID 481520 reaction equation
[C:1]([CH2:3][C:4](C1C=CC(OC)=C(C=1)C=O)(C)C)#N.[ClH:17].Cl.[C:19]1([C@H:25]2[C@@H:30]([NH2:31])[CH2:29][CH2:28][CH2:27][NH:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.Cl.Cl.[C:34]([C:36]1([C:39]2[CH:40]=[CH:41][C:42]([O:59][CH3:60])=[C:43]([CH:58]=2)[CH2:44]N[C@H]2CCCN[C@H]2C2C=CC=CC=2)[CH2:38][CH2:37]1)#[N:35]>>[ClH:17].[ClH:17].[C:34]([C:36]1([C:39]2[CH:40]=[CH:41][C:42]([O:59][CH3:60])=[C:43]([CH:58]=2)[CH2:44][NH:31][C@H:30]2[CH2:29][CH2:28][CH2:27][NH:26][C@H:25]2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:38][CH2:37][CH2:4][CH2:3][CH2:1]1)#[N:35]

Participants

4

Procedure

This compound was prepared from Compound 47 and Compound 3 in the same manner of Compound 5.

Sources & evidence

ORD record
ord-1b74814a7b3949238b5b247d70f44289
Source dataset
uspto-grants-1998_08
Patent number
US05789423

Linked notes

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