[2-(4-Hydroxyphenyl)-benzofuran-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl] methanone hydrochloride → [2-(4-Hydroxyphenyl)-benzofuran-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanol
Reaction equation
Cl.[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[CH:34]=[CH:33][CH:32]=[CH:31][C:12]=3[C:13]=2[C:14]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:18][CH:17]=2)=[O:15])=[CH:5][CH:4]=1>CO>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[CH:34]=[CH:33][CH:32]=[CH:31][C:12]=3[C:13]=2[CH:14]([C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][N:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]3)=[CH:20][CH:21]=2)[OH:15])=[CH:5][CH:4]=1Participants
3
Procedure
2.0 g (4.23 mmol) of [2-(4-hydroxyphenyl)-benzofuran-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl] methanone hydrochloride was reduced to the carbinol using the method described in Example 1. This yielded 1.59 g of the title compound as an amorphous powder.