Hydrochloric Acid → 5-[(4-Nitrophenyl)methyl]imidazolidine-2,4-dione

Participants

Reaction Steps

A solution of p-nitrophenylalanine (4.2 g, Fluka) and potassium cyanate (1.62 g) in water (6 ml) was refluxed for 1 hour. C.HCl (3 ml) was added and the mixture refluxed for a further 10 minutes, then cooled, diluted with water and filtered. The residue was washed with water and dried to give the desired product as a straw-coloured solid (3.85 g). The 200 MHz 1H NMR was consistent with the proposed structure.

Provenance & Evidence