Water → N-(2,3-Dihydro-1H-inden-2-yl)acetamide
Reaction equation
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:11](OC(=O)C)(=[O:13])[CH3:12].O>N1C=CC=CC=1>[C:11]([NH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)(=[O:13])[CH3:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
2-aminoindan (6.0 g, 45 mmol) was dissolved in dry pyridine (7 ml), to which acetic anhydride (4.5 ml, 47.3 mmol) was added dropwise while cooling in ice water. After the reaction mixture was returned to room temperature and stirred for 20 minutes, water was added. The precipitate that deposited was filtered to obtain 2-acetamidoindan (5.6 g, 32 mmol).
Workup
- additionwas added dropwise
- customwas returned to room temperature
- filtrationThe precipitate that deposited was filtered
Sources & evidence
- ORD record
- ord-98d057ea4c4f49e8bf8e66ae144e62ee
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06703421B1
Reaction notes
Loading…