Formamide → HCID 178518069, compound

Reaction equation

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)[C:6]=1[C:7](OCC)=[O:8].[CH:17]([NH2:19])=O>>[O:13]1[CH:14]=[CH:15][CH:16]=[C:12]1[C:5]1[C:6]2[C:7]([OH:8])=[N:19][CH:17]=[N:1][C:2]=2[S:3][CH:4]=1

Participants

Reactant 2

HCID 713Formamide

HCID 736628Ethyl 2-amino-4-(2-furyl)thiophene-3-carboxylate

Product 1

HCID 178518069HCID 178518069, compound

Procedure

Ethyl 2-amino-4-(2-furyl)thiophene-3-carboxylate (500 mg, 2.1 mmol) in formamide (4 ml) was stirred at 180° C. for 3 hours. The precipitate obtained by cooling the reaction mixture was filtered to obtain 5-(2-furyl)-4-hydroxythieno[2,3-d]pyrimidine (330 mg, 1.5 mmol) having the following physical properties:

Workup

customThe precipitate obtained
temperatureby cooling the reaction mixture
filtrationwas filtered

Sources & evidence

ORD record: ord-43803cbfbb4446edb10e189fe92114dd
Source dataset: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06703421B1

Reaction notes

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