HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 2-Aminoindan-5-carboxylic acid morpholinamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 2-(Tert-butoxycarbonylamino)indan-5-carboxylic acid morpholinamide | HCID 131724366 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Aminoindan-5-carboxylic acid morpholinamide hydrochloride | HCID 69849846 | — |
Reaction Steps
Using 2-(tert-butoxycarbonylamino)indan-5-carboxylic acid morpholinamide (1.0 g, 2.7 mmol), 4N hydrochloric acid-dioxane (12 ml) and acetic acid (36 ml), a similar procedure to Production Example 213 was carried out to obtain 2-aminoindan-5-carboxylic acid morpholinamide hydrochloride (750 mg, 2.7 mmol) having the following physical properties:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06703421B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-fa21e3f9e6904a029afbc3594e1dbb39 |
| Source note | uspto-grants-2004_03 |