4-Fluorophenylboronic acid → Emd-50929

HRID 48469

Reaction equation

HRID 48469 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[C:12]([CH:17]=2)[C:13]([O:15]C)=[O:14])=[CH:4][CH:3]=1.BrC1C=C(C(OC)=O)C=NC=1.FC1C=CC(B(O)O)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[C:12]([CH:17]=2)[C:13]([OH:15])=[O:14])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 2856454-Fluorophenylboronic acidHCID 699336Methyl 5-bromopyridine-3-carboxylateHCID 22743456Methyl 5-(4-fluorophenyl)nicotinate

Product 1

HCID 11378949Emd-50929

Procedure

15.3 g of methyl 5-(4-fluorophenyl)nicotinate (obtainable by Suzuki coupling of methyl 5-bromopyridine-3-carboxylate with 4-fluorobenzeneboronic acid analogously to Example 1 or 2) are saponified by conventional methods to give 5-(4-fluorophenyl)nicotinic acid.

Sources & evidence

ORD record
ord-cd26b86a68d2414683332086861e6679
Source dataset
uspto-grants-2004_03
Patent number
US06703509B2

Linked notes

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