1-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinone → 3-Isobutyl-1-methyl-piperazin-2-one
Reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5](CC2C=CC=CC=2)[CH:4]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:3]1=[O:19].[H][H]>CO.[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH:4]([CH2:15][CH:16]([CH3:17])[CH3:18])[C:3]1=[O:19]Participants
5
Procedure
1-Methyl-3-(2-methylpropyl-4-(phenylmethyl)piperazinone (Example 47, 2.1 g.) is dissolved in methanol (200 ml.), 10% palladium charcoal (1.0 g.) is added and the product is hydrogenated (50 lb. initial hydrogen pressure until the uptake of hydrogen ceased. The solution is filtered and the methanol is removed under reduced pressure to give the title compound as an oil.
Workup
- filtrationThe solution is filtered
- customthe methanol is removed under reduced pressure
Sources & evidence
- ORD record
- ord-767e9111f8674f5ea0537ba433f0226d
- Source dataset
- uspto-grants-1985_08
- Patent number
- US04534897
Reaction notes
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