4-Amino-2-methylpyrimidine-5-carbaldehyde → 4-Amino-2-methyl-5-pyrimidinemethanamine

HRID 485482

Reaction equation

HRID 485482 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH:9]=O)=[CH:4][N:3]=1.[NH3:11].CO>O[Mo](O)(=O)=O>[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][NH2:11])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 129047264-Amino-2-methylpyrimidine-5-carbaldehydeHCID 21705897Ammonia methanol

Product 1

HCID 667624-Amino-2-methyl-5-pyrimidinemethanamineYield 93.5%

Reagents, catalysts & solvents 1

HCID 82208Molybdic acidCatalyst

Procedure

Into an Erlenmeyer's flask of 100 ml, 2.00 g (14.6 millimole) of 2-methyl-4-amino-5-formylpyrimidine, 40 g of 20 wt. % ammonia-methanol solution and 2.0 mg of molybdic acid (H2MoO4.H2O) were added, and the mixture was stirred for 2 hours under room temperature, with the flask being closely stoppered. Following subsequently the same procedure as in Example 1, 2-methyl-4-amino-5-aminomethylpyrimidine was obtained at a yield of 93.5%.

Sources & evidence

ORD record
ord-c829ba66a22041189243bf237dd00d53
Source dataset
uspto-grants-1985_08
Patent number
US04536577

Linked notes

Loading…