Indazolinone → HCID 178463272, compound

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([OH:10])=[N:2]1.[CH2:11]([N:13]1C(=O)O[C:16](=[O:17])[C:15]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:14]12)[CH3:12]>>[CH2:11]([NH:13][C:14]1[CH:24]=[CH:23][CH:22]=[CH:21][C:15]=1[C:16]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([OH:10])=[N:2]1)=[O:17])[CH3:12]

Participants

Reactant 2

HCID 81829Indazolinone

HCID 3249856N-ethylisatoic anhydride

Product 1

HCID 178463272HCID 178463272, compoundYield 47.7%

Procedure

1H-Indazol-3-ol was reacted with N-ethylisatoic anhydride according to the general procedure A above and afforded the desired amine as a canary yellow solid, in 47.7% yield; m.p. 163°-165° C.

Sources & evidence

ORD record: ord-85b099dcba484a6aaf54aeab0530acb7
Source dataset: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04537966

Reaction notes

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