Indazolinone → HCID 178456741, compound

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([OH:10])=[N:2]1.[CH:11]([N:14]1C(=O)O[C:17](=[O:18])[C:16]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:15]12)([CH3:13])[CH3:12]>>[CH:11]([NH:14][C:15]1[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=1[C:17]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([OH:10])=[N:2]1)=[O:18])([CH3:13])[CH3:12]

Participants

Reactant 2

HCID 81829Indazolinone

HCID 39125701-(Propan-2-yl)-2H-3,1-benzoxazine-2,4(1H)-dione

Product 1

HCID 178456741HCID 178456741, compoundYield 71.3%

Procedure

1H-Indazol-3-ol was reacted with N-isopropylisatoic anhydride according to the general procedure A above and afforded the desired amine as a yellow solid in 71.3% yield; m.p. 190°-192° C.

Sources & evidence

ORD record: ord-edb11c39280b447e934e311f8d912d60
Source dataset: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04537966

Reaction notes

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