Indazolinone → HCID 178482184, compound

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([OH:10])=[N:2]1.[CH3:11][N:12]1C(=O)O[C:15](=[O:16])[C:14]2=[CH:20][CH:21]=[C:22]([Cl:24])[CH:23]=[C:13]12>>[CH3:11][NH:12][C:13]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:14]=1[C:15]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([OH:10])=[N:2]1)=[O:16]

Participants

Reactant 2

HCID 81829Indazolinone

HCID 110529544-chloro-N-methylisatoic anhydride

Product 1

HCID 178482184HCID 178482184, compoundYield 53.5%

Procedure

1H-Indazol-3-ol was reacted with N-methyl-4-chloroisatoic anhydride according to the general procedure A above and afforded the desired amine as a yellow solid in 53.5% yield; m.p. 209°-211° C.

Sources & evidence

ORD record: ord-c21228e7df534d5a801d86000bbb60b0
Source dataset: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04537966

Reaction notes

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