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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 48622Generated: October 26, 2026

(+-)-Tetrahydropapaverine → 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide

https://huagongshe.com/reaction/48622

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(+-)-TetrahydropapaverineHCID 5418—
Reactant1,2,3,4-Tetrahydro-1-naphthylamineHCID 18066—
ReactantBromoacetyl bromideHCID 61147—
Product2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamideHCID 22742523—

Reaction Steps

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06703392B2
Source datasetuspto-grants-2004_03
ORD IDord-8c5dbaa534f84470bc6ee97f7fe6e0ab
Source noteuspto-grants-2004_03