Lithium Chloride → Cyclopentanone, 2-(2-methyl-2-propenyl)-
Reaction equation
COC([C:5]1([CH2:11][C:12]([CH3:14])=[CH2:13])[CH2:9][CH2:8][CH2:7][C:6]1=[O:10])=O.[Li+].[Cl-]>CN(P(N(C)C)(N(C)C)=O)C>[CH3:14][C:12](=[CH2:13])[CH2:11][CH:5]1[CH2:9][CH2:8][CH2:7][C:6]1=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 73 °C
Procedure
A mixture of methyl-1-(2-methyl-2-propenyl)-2-oxo-1-cyclopentanecarboxylate (78.4 g), HMPA (hexamethylphosphoramide, 250 ml) and LiCl (34 g) is heated to 73° C. for 36 hrs. Extraction (3 times, ether/water) of the reaction product provides a brown oil which, upon fractional distillation (63° C.-75° C./5.32×102Pa), yields 2-(2-methyl-2-propenyl)-1-cyclopentanone.
Workup
- extractionExtraction (3 times, ether/water) of the reaction product
- customprovides a brown oil which
- distillationupon fractional distillation (63° C.-75° C./5.32×102Pa)
Sources & evidence
- ORD record
- ord-9c32e307e20b402b87209b0f4dc12dd7
- Source dataset
- uspto-grants-1994_03
- Patent number
- US05292719
Reaction notes
Loading…