4-tert-Butylbenzenesulfonamide → p-tert-butyl-N-[6-(2-hydroxyethoxy)-5(o-methoxyphenoxy)-2-(trifluoromethyl)-4-pyrimidinyl]benzenesulfonamide

HRID 486640

Reaction equation

HRID 486640 reaction equation
Cl[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH3:16])=[C:6](Cl)[N:5]=[C:4]([C:18]([F:21])([F:20])[F:19])[N:3]=1.[C:22]([C:26]1[CH:31]=[CH:30][C:29]([S:32]([NH2:35])(=[O:34])=[O:33])=[CH:28][CH:27]=1)([CH3:25])([CH3:24])[CH3:23]>C1(C)C=CC=CC=1>[C:22]([C:26]1[CH:31]=[CH:30][C:29]([S:32]([NH:35][C:2]2[C:7]([O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[O:15][CH3:16])=[C:6]([O:8][CH2:9][CH2:10][OH:15])[N:5]=[C:4]([C:18]([F:21])([F:20])[F:19])[N:3]=2)(=[O:33])=[O:34])=[CH:28][CH:27]=1)([CH3:25])([CH3:23])[CH3:24]

Participants

4

Reactant 2

HCID 2228724-tert-ButylbenzenesulfonamideHCID 181842644,6-Dichloro-5-(2-methoxyphenoxy)-2-trifluoromethylpyrimidine

Product 1

HCID 19095722p-tert-butyl-N-[6-(2-hydroxyethoxy)-5(o-methoxyphenoxy)-2-(trifluoromethyl)-4-pyrimidinyl]benzenesulfonamide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

By reacting 4,6-dichloro-5-(2-methoxyphenoxy)-2-trifluoromethylpyrimidine with p-tert-butylbenzenesulfonamide and with ethylene glycol Na there was obtained p-tert-butyl-N-[6-(2-hydroxyethoxy)-5(o-methoxyphenoxy)-2-(trifluoromethyl)-4-pyrimidinyl]benzenesulfonamide, m.p. 190°-192° C. (from toluene). Sodium salt: M.p. 288°-289° C.

Sources & evidence

ORD record
ord-fdd360d13d074b359c24049046676f2f
Source dataset
uspto-grants-1994_03
Patent number
US05292740

Linked notes

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