HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate | HCID 10980693 | — |
| Reactant | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | Methyl 2-(4-aminobutoxy)-6-hydroxybenzoate | HCID 11832643 | — |
Reaction Steps
Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate (410 mg, 1.2 mmol) was treated with trifluoroacetic acid/dichloromethane (6 mL, 1:1/v:v) at ambient temperature for 3 hours, concentrated under reduced pressure and evaporated with acetonitrile twice to provide the titled amine as its trifluoroacetic acid salt (450 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06972340B2 |
| Source dataset | uspto-grants-2005_12 |
| ORD ID | ord-568236dc42d244379cbec0ebfbe7e366 |
| Source note | uspto-grants-2005_12 |