Bromine → 2-Bromo-1,3-diphenyl-1-propanone

HRID 488770

Reaction equation

HRID 488770 reaction equation
[C:1]1([C:7](=[O:16])[CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:17]Br>O1CCOCC1>[Br:17][CH:8]([CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:16]

Participants

4

Reactant 2

HCID 24408BromineHCID 64802Dihydrochalcone2×

Product 1

HCID 30396872-Bromo-1,3-diphenyl-1-propanone

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 1,3-diphenylpropan-1-one (compound 2) (7.0 mmol) in 25 ml of anhydrous dioxane, a solution of bromine (7.0 mmol) in 10 ml of dioxane was slowly added dropwise over 30 min. The reaction mixture was left to stir at room temperature for 24 hrs to form 2-bromo-1,3-diphenylpropan-1-one (compound 3). Solvent was removed in vacuo. The 2-bromo-1,3-diphenylpropan-1-one product formed was determined by 1H NMR to be sufficiently pure to be used in the next step.

Workup

  1. waitThe reaction mixture was left

Sources & evidence

ORD record
ord-7893031004964d65825ebce55d7a7866
Source dataset
uspto-grants-2005_12
Patent number
US06974830B2

Linked notes

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