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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 48950Generated: October 23, 2026

1-Ethynyl-4-fluorobenzene → 2-(4-Fluoro-phenylethynyl)-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester

https://huagongshe.com/en/reaction/48950

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethynyl-4-fluorobenzeneHCID 522627—
Reactantethyl 2-bromo-1,4-dimethyl-1H-imidazole-5-carboxylateHCID 13897513—
Product2-(4-Fluoro-phenylethynyl)-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl esterHCID 9921942—

Reaction Steps

The title compound, MS: m/e=286.8 (M+H+) was prepared in accordance with the general method of example 1b from 2-bromo-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester and 1-ethynyl-4-fluorobenzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06706707B2
Source datasetuspto-grants-2004_03
ORD IDord-d56eeaa95c2d46e6a202b9876aa2c03c
Source noteuspto-grants-2004_03