Indole-5-carboxaldehyde → 3-(1H-Indol-5-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide

Reaction equation

[NH2:1][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3].[NH:15]1[C:23]2[C:18](=[CH:19][C:20]([CH:24]=O)=[CH:21][CH:22]=2)[CH:17]=[CH:16]1>>[NH:15]1[C:23]2[C:18](=[CH:19][C:20]([CH:24]=[C:8]3[C:7]4[C:11](=[CH:12][CH:13]=[C:5]([S:2]([NH2:1])(=[O:4])=[O:3])[CH:6]=4)[NH:10][C:9]3=[O:14])=[CH:21][CH:22]=2)[CH:17]=[CH:16]1

Participants

Reactant 2

HCID 589040Indole-5-carboxaldehyde

HCID 101982322-Oxoindoline-5-sulfonamide

Product 1

HCID 540004633-(1H-Indol-5-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide

Procedure

5-Aminosulfonyl-2-oxindole was condensed with indole-5-carbaldehyde to give the title compound.

Sources & evidence

ORD record: ord-c4bda0720bd04f878c3819a4fb1c78de
Source dataset: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06706709B2

Reaction notes

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