HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 491213Generated: October 24, 2026
Water → 1-(2-(2-Methoxy-4-nitrophenoxy)ethyl)pyrrolidine
https://huagongshe.com/en/reaction/491213
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-(2-Chloroethyl)pyrrolidine hydrochloride | HCID 81668 | — |
| Reactant | HCID 14144719 | HCID 14144719 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-(2-Methoxy-4-nitrophenoxy)ethyl)pyrrolidine | HCID 17989355 | — |
Reaction Steps
A suspension of potassium 2-methoxy-4-nitro-phenolate (2.0 g, 9.7 mmol), 1-(2-chloro-ethyl)-pyrrolidine hydrochloride (2.0 g, 12 mmol) and cesium carbonate (7.0, 22 mmol) in DMF (35 mL) was heated at 80° C. for 16 h. The mixture was allowed to cool to room temperature, poured into water (60 mL) and extracted with EtOAc (2×50 mL). The combined extracts were washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated and used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07528143B2 |
|---|
| Source dataset | uspto-grants-2009_05 |
|---|
| ORD ID | ord-c3f8596d21e044b3802d5d13715720ab |
|---|
| Source note | uspto-grants-2009_05 |
|---|
