[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol → 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

HRID 491293Notes

Reaction equation

HRID 491293 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH2:13][OH:14])[N:10]=[C:9]2[CH3:15])=[CH:4][CH:3]=1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([CH:13]=[O:14])[N:10]=[C:9]2[CH3:15])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 67303957[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol

Product 1

HCID 859979931-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol is dissolved in methylene chloride. Manganese (IV) oxide is added and the reaction mixture is stirred at room temperature for 3 days. The suspension is filtered through a dicalite speed plus pad and the desired compound (4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde is obtained.

Workup

  1. filtrationThe suspension is filtered through a dicalite speed plus pad

Sources & evidence

ORD record
ord-8b897ca23539406ab8a06219ab41d833
Source dataset
uspto-grants-2009_05
Patent number
US07531529B2

Reaction notes

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