4-(2-Bromoethyl)benzoic acid → (3-Bromomethyl-phenyl)-acetic acid methyl ester

Reaction equation

[Br:1][CH2:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.Br[CH2:14]CC1C=CC(C(O)=O)=CC=1>>[Br:1][CH2:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([O:12][CH3:14])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 1040684-(2-Bromoethyl)benzoic acid

HCID 103765092-(3-(Bromomethyl)phenyl)acetic acid

Product 1

HCID 10014651(3-Bromomethyl-phenyl)-acetic acid methyl ester

Procedure

According to the procedures described in the synthesis method of Intermediate ia-01, 2-[3-(bromomethyl)phenyl]acetic acid (500 mg) synthesized according to the procedures described in International Patent Publication WO00/03980 was used instead of 4-(2-bromoethyl)benzoic acid, and the material was reacted and treated to obtain the title compound (Intermediate il-01, 471 mg).

Workup

customdescribed in the synthesis method of Intermediate ia-01
customthe material was reacted
additiontreated

Sources & evidence

ORD record: ord-e81e3e2667644b58b5b66d36e6efaf1e
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07531533B2

Reaction notes

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