2,4-Difluoroacetophenone → 6-(2,4-Difluorophenyl)nicotinic acid

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[CH3:10].FC1C=CC(C2C=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=2)=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=1

Participants

Reactant 2

HCID 677702,4-Difluoroacetophenone

HCID 227301866-(4-Fluorophenyl)nicotinic acid

Product 1

HCID 247299856-(2,4-Difluorophenyl)nicotinic acid

Procedure

The title compound was prepared from 2′,4′-difluoroacetophenone using the procedures outlined for 6-(4-fluorophenyl)nicotinic acid (D1-D3).

Sources & evidence

ORD record: ord-695bcc4cb9694d79be18d195c1f8a621
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07531558B2

Reaction notes

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