1-(3,4-Difluorophenyl)ethan-1-one → 6-(3,4-Difluorophenyl)pyridine-3-carboxylic acid

HRID 491568

Reaction equation

HRID 491568 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].FC1C=CC(C2C=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=2)=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 1230521-(3,4-Difluorophenyl)ethan-1-oneHCID 227301866-(4-Fluorophenyl)nicotinic acid

Product 1

HCID 529840926-(3,4-Difluorophenyl)pyridine-3-carboxylic acid

Procedure

The title compound was prepared from 3′,4′-difluoroacetophenone using the procedures outlined for 6-(4-fluorophenyl)nicotinic acid (D1-D3).

Sources & evidence

ORD record
ord-cdc2fe2ac3ce4e93b39da8a16d8ea2ba
Source dataset
uspto-grants-2009_05
Patent number
US07531558B2

Linked notes

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