HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Cyclopentanedicarboxylic anhydride → 3-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-3-azabicyclo[3.2.1]octane-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Cyclopentanedicarboxylic anhydride | HCID 239799 | — |
| Reactant | 4-(2-Pyrimidinyl)-1-piperazinebutanamine | HCID 12840705 | — |
| Product | 3-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-3-azabicyclo[3.2.1]octane-2,4-dione | HCID 14156355 | 34% |
Reaction Steps
The title compound was prepared from 1.92 g (8.2 mmol) of 1-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine and 1.14 g (8.14 mmol) of 3-oxabicyclo[3.2.1]octan-2,4-dione, substantially following the procedure of Example 1. Yield: 1.0 g (34% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242911 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-ff612c52e1a04b8e97b7f6d47d01eb91 |
| Source note | uspto-grants-1993_09 |