4-(Methylamino)cyclohexanecarbonitrile → (1-{2-[(4-cyano-cyclohexyl)-methyl-carbamoyl]-ethyl}-2-methyl-(S)-propyl)-carbamic tert-butyl ester
Reaction equation
[CH3:1][NH:2][CH:3]1[CH2:8][CH2:7][CH:6]([C:9]#[N:10])[CH2:5][CH2:4]1.[C:11]([O:15][C:16]([NH:18][C@H:19]([CH:25]([CH3:27])[CH3:26])[CH2:20][CH2:21][C:22]([OH:24])=O)=[O:17])([CH3:14])([CH3:13])[CH3:12]>>[C:11]([O:15][C:16](=[O:17])[NH:18][C@@H:19]([CH2:20][CH2:21][C:22](=[O:24])[N:2]([CH:3]1[CH2:8][CH2:7][CH:6]([C:9]#[N:10])[CH2:5][CH2:4]1)[CH3:1])[CH:25]([CH3:27])[CH3:26])([CH3:12])([CH3:13])[CH3:14]Participants
3
Procedure
Following the procedure as described in Example 25, STEP E, 4-methyamino-cyclohexanecarbonitrile and 4-(S)-tert-butoxycarbonylamino-5-methyl-hexanoic acid were reacted to yield (1-{2-[(4-cyano-cyclohexyl)-methyl-carbamoyl]-ethyl}-2-methyl-(S)-propyl)-carbamic tert-butyl ester as a lightly colored oil was prepared.
Workup
- customwere reacted