HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,5-Dimethyl-3-oxabicyclo[3.2.1]octan-2,4-dione → 3-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl)-1, 5-dimethyl-3-azabicyclo[3.2.1]octan-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,5-Dimethyl-3-oxabicyclo[3.2.1]octan-2,4-dione | HCID 12530271 | — |
| Reactant | 4-(2-Pyrimidinyl)-1-piperazinebutanamine | HCID 12840705 | — |
| Product | 3-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl)-1, 5-dimethyl-3-azabicyclo[3.2.1]octan-2,4-dione | HCID 14097166 | 21% |
Reaction Steps
Following substantially the procedure of Example 1, 4.2 g (17.8 mmol) of 1-(4-aminobutyl)-4-(2-pyrimidinyl) piperazine was reacted with 2.99 g (17.8 mmol) of 1,5-dimethyl-3-oxabicyclo[3.2.1]octan-2,4-dione. The product was chromatographed on silica gel, eluting with dichloromethane/methanol (96:4), to give 1.4 g (21% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242911 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-e56e486a103f4058a11eaf6d3e707e63 |
| Source note | uspto-grants-1993_09 |