Water → Pyrazol-5(4H)-one, 1-(2-benzothiazolyl)-3-methyl-
Reaction equation
[NH:1]([C:3]1[S:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1)[NH2:2].[OH2:12]>C(O)(=O)C>[S:4]1[C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=[C:3]1[N:1]1[C:8](=[O:12])[CH2:6][C:5]([CH3:11])=[N:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2 g (12.1 mmol) of 2-hydrazino-1,3-benzothiazole and 1.58 g (12.1 mmol) of acetoacetic ester are stirred in 40 ml of glacial acetic acid for 2 hours at 90° C. The mixture is then diluted with water and the precipitated crystals are filtered off with suction, washed again with water and dried under reduced pressure.
Workup
- filtrationthe precipitated crystals are filtered off with suction
- washwashed again with water
- customdried under reduced pressure
Sources & evidence
- ORD record
- ord-75391b813e274a8b95e1542c76834bcb
- Source dataset
- uspto-grants-2009_05
- Patent number
- US07534273B2
Reaction notes
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