Water → Pyrazol-5(4H)-one, 1-(2-benzothiazolyl)-3-methyl-

HRID 493008

Reaction equation

HRID 493008 reaction equation
[NH:1]([C:3]1[S:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1)[NH2:2].[OH2:12]>C(O)(=O)C>[S:4]1[C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=[C:3]1[N:1]1[C:8](=[O:12])[CH2:6][C:5]([CH3:11])=[N:2]1

Participants

4

Reactant 2

HCID 962WaterHCID 119882-Benzothiazolinone, hydrazone

Product 1

HCID 459449Pyrazol-5(4H)-one, 1-(2-benzothiazolyl)-3-methyl-

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2 g (12.1 mmol) of 2-hydrazino-1,3-benzothiazole and 1.58 g (12.1 mmol) of acetoacetic ester are stirred in 40 ml of glacial acetic acid for 2 hours at 90° C. The mixture is then diluted with water and the precipitated crystals are filtered off with suction, washed again with water and dried under reduced pressure.

Workup

  1. filtrationthe precipitated crystals are filtered off with suction
  2. washwashed again with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-75391b813e274a8b95e1542c76834bcb
Source dataset
uspto-grants-2009_05
Patent number
US07534273B2

Linked notes

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