2-Fluoro-6-nitroaniline → 3-Fluorobenzene-1,2-diamine

HRID 493121

Reaction equation

HRID 493121 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[NH2:11]>C(O)C.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[NH2:11]

Participants

4

Reactant 1

HCID 873162-Fluoro-6-nitroaniline

Product 1

HCID 27828353-Fluorobenzene-1,2-diamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2-fluoro-6-nitro-phenylamine [K. L. Kirk and L. A. Cohen J. Org. Chem. 34, 384-389 (1969)] (1.05 g) in ethanol (50 ml) was hydrogenated over 10% palladium on carbon (0.5 g), filtered and evaporated to give a brown solid, used without purification.

Workup

  1. filtrationfiltered
  2. customevaporated
  3. customto give a brown solid
  4. customused without purification

Sources & evidence

ORD record
ord-c493ca06571448c0add5b9ae3bca65e2
Source dataset
uspto-grants-2009_05
Patent number
US07534793B2

Linked notes

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