1,2-Benzenedicarboxylic acid, 4-nitro- → 4-Aminophthalic acid
Reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9])([O-])=O>C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9]Participants
3
Reagents, catalysts & solvents 1
Procedure
1 g (4.73 mmol) of 4-nitrophthalic acid is dissolved in 10 mL of anhydrous ethanol. The solution is stirred at room temperature and degassed under argon. 50 mg of palladium/charcoal (5%) are added in a single portion and hydrogen is bubbled into the solution. After 3 hours, the solution is filtered through Celite and then evaporated.
Workup
- customdegassed under argon
- addition50 mg of palladium/charcoal (5%) are added in a single portion and hydrogen
- customis bubbled into the solution
- filtrationthe solution is filtered through Celite
- customevaporated
Sources & evidence
- ORD record
- ord-d56bdbc58160413788ea7d8ded70198f
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06706725B1
Reaction notes
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