1,2-Benzenedicarboxylic acid, 4-nitro- → 4-Aminophthalic acid

HRID 49317

Reaction equation

HRID 49317 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9])([O-])=O>C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9]

Participants

3

Reactant 1

HCID 691211,2-Benzenedicarboxylic acid, 4-nitro-

Product 1

HCID 729124-Aminophthalic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 g (4.73 mmol) of 4-nitrophthalic acid is dissolved in 10 mL of anhydrous ethanol. The solution is stirred at room temperature and degassed under argon. 50 mg of palladium/charcoal (5%) are added in a single portion and hydrogen is bubbled into the solution. After 3 hours, the solution is filtered through Celite and then evaporated.

Workup

  1. customdegassed under argon
  2. addition50 mg of palladium/charcoal (5%) are added in a single portion and hydrogen
  3. customis bubbled into the solution
  4. filtrationthe solution is filtered through Celite
  5. customevaporated

Sources & evidence

ORD record
ord-d56bdbc58160413788ea7d8ded70198f
Source dataset
uspto-grants-2004_03
Patent number
US06706725B1

Linked notes

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