Pyridine → Glycidyl benzoate

Temperature

0 °C

Benzoyl chloride (1.2 mL, 10.0 mmol) was added to a solution of glycidol (0.67 mL, 10.0 mmol) and pyridine (0.81 mL, 10.0 mmol) in anhydrous dichloromethane at 0° C. The reaction mixture was further stirred at 0° C. for 60 min. The reaction mixture was then concentrated to dryness under reduced pressure, diluted with ethyl acetate, and washed with 10% citric acid twice followed by the addition of a saturated NaHCO3 solution and brine. The organic phase was dried over MgSO4 and concentrated to dryness to yield 1.8 g (100%) of Oxiran-2-ylmethyl benzoate.

1. concentrationThe reaction mixture was then concentrated to dryness under reduced pressure
2. additiondiluted with ethyl acetate
3. washwashed with 10% citric acid
4. additiontwice followed by the addition of a saturated NaHCO3 solution and brine
5. dry with materialThe organic phase was dried over MgSO4
6. concentrationconcentrated to dryness

ORD record

ord-b1b61786359d472c9f866df042ebf831

Source dataset

uspto-grants-2009_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07534813B2