HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromothiophene-2-carbaldehyde → 1-(4-Bromo-2-thienyl)-1-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromothiophene-2-carbaldehyde | HCID 87792 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Bromo-2-thienyl)-1-propanol | HCID 22606901 | — |
Reaction Steps
30 g (157 mmol) of 4-bromo-2-thiophenecarboxaldehyde are dissolved in 200 mL of anhydrous THF. 104 mL (312 mmol) of 3.0 M ethylmagnesium bromide are added slowly and the medium is stirred for 2 hours at room temperature. After the usual treatment, an orange-coloured oil is obtained (m=33.5 g; Y=96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06706725B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-b2bca1c410a54470a65e171b381e8a24 |
| Source note | uspto-grants-2004_03 |