4-Bromo-2-propionylthiophene → (e)-5-(4-Bromo-2-thienyl)-4-heptenoic acid

Participants

Reaction Steps

In a manner similar to that of Example 6(i), by reaction of 16 g (73 mmol) of 1-(4-bromo-2-thienyl)-1-propanone with 47 g (109 mmol) of (3-carboxypropyl)triphenylphosphonium bromide and 24.6 g (219 mmol) of potassium tert-butoxide, the desired product is obtained in the form of an orange-coloured solid (m=16.7 g; Y=80%).

Provenance & Evidence