Methyl (R)-(1-hydroxy-3-methylbutan-2-YL)carbamate → (4R)-4-(Propan-2-yl)-1,3-oxazolidin-2-one

HRID 4940

Reaction equation

HRID 4940 reaction equation
CO[C:3]([NH:5][C@@H:6]([CH2:10][OH:11])[CH:7]([CH3:9])[CH3:8])=[O:4]>C1(C)C=CC=CC=1>[CH3:9][CH:7]([C@@H:6]1[CH2:10][O:11][C:3](=[O:4])[NH:5]1)[CH3:8]

Participants

3

Reactant 1

HCID 15714133Methyl (R)-(1-hydroxy-3-methylbutan-2-YL)carbamate

Product 1

HCID 641505(4R)-4-(Propan-2-yl)-1,3-oxazolidin-2-one

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
150 °C

Procedure

27.2 g (168.7 mmol) of the compound from Example V are dissolved in 400 ml of toluene and stirred under reflux in an oil bath at 150° C. while passing in nitrogen.

Sources & evidence

ORD record
ord-14e133718ef4419f957fbad21214f7e7
Source dataset
uspto-grants-1993_09
Patent number
US05242903

Linked notes

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