Ethanol → 4-Ethoxycarbonylphenylboronic acid

HRID 49422

Reaction equation

HRID 49422 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([B:10]([OH:12])[OH:11])=[CH:6][CH:5]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>>[CH2:18]([O:2][C:1]([C:4]1[CH:5]=[CH:6][C:7]([B:10]([OH:12])[OH:11])=[CH:8][CH:9]=1)=[O:3])[CH3:19]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 3121834-Carboxyphenylboronic Acid

Product 1

HCID 27343504-Ethoxycarbonylphenylboronic acid

Procedure

A solution of 4-carboxyphenylboronic acid (15 g, 0.09 mol), 99% ethanol (150 mL) and concentrated sulphuric acid (0.5 mL) was heated to reflux for two days. The volume was reduced to approximately 20 mL. The residue was triturated with petroleum ether to give 13.4 g of the desired material.

Workup

  1. temperatureto reflux for two days
  2. customThe residue was triturated with petroleum ether

Sources & evidence

ORD record
ord-bf48985882e84c38afed626b7b44b7a8
Source dataset
uspto-grants-2004_03
Patent number
US06706749B2

Linked notes

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