7-Aminoquinoline → 6-(2-Fluorophenyl)-N-quinolin-7-yl-nicotinamide

HRID 494270Notes

Reaction equation

HRID 494270 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][N:20]=1>>[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:1][C:2]2[CH:11]=[C:10]3[C:5]([CH:6]=[CH:7][CH:8]=[N:9]3)=[CH:4][CH:3]=2)=[O:24])=[CH:21][N:20]=1

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 247299716-(2-Fluorophenyl)nicotinic acid

Product 1

HCID 445788946-(2-Fluorophenyl)-N-quinolin-7-yl-nicotinamide

Procedure

Using the procedure outlined in Example 104, the title compound was prepared from 7-aminoquinoline (D55) (28 mg, 0.19 mmol) and 6-(2-fluorophenyl)-nicotinic acid (D74) (50 mg, 0.23 mmol) as a yellow solid. MS(ES): MH+ 344, M-H+ 342

Sources & evidence

ORD record
ord-c9366ac6fd894af88ca7e33733338755
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

Loading…