7-Aminoquinoline → HCID 57682745, compound

HRID 494275Notes

Reaction equation

HRID 494275 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25](O)=[O:26])=[CH:21][C:20]=2[O:28][CH2:29][CH2:30][O:31][CH3:32])=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([NH:1][C:2]3[CH:11]=[C:10]4[C:5]([CH:6]=[CH:7][CH:8]=[N:9]4)=[CH:4][CH:3]=3)=[O:26])=[CH:21][C:20]=2[O:28][CH2:29][CH2:30][O:31][CH3:32])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 690396114'-Fluoro-2-(2-methoxyethoxy)-1,1'-biphenyl-4-carboxylic acid

Product 1

HCID 57682745HCID 57682745, compound

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (21 mg, 0.14 mmol) and 4′-fluoro-2-(2-methoxyethoxy)-1,1′-biphenyl-4-carboxylic acid (D77) (50 mg, 0.17 mmol) as an orange solid. MS(ES): MH+ 417, M-H+ 415

Sources & evidence

ORD record
ord-e400fb0cb3004b98be930d910ab57bd1
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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