Dibenzyl malonate → 3-Ethoxycarbonyl-4-nitrophenylmalonic acid dibenzyl ester

HRID 494411

Reaction equation

[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[C:9](Cl)[CH:8]=[CH:7][C:6]=1[N+:12]([O-:14])=[O:13])[CH3:2].[CH2:16]([O:23][C:24](=[O:36])[CH2:25][C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:29]([O:28][C:26](=[O:27])[CH:25]([C:9]1[CH:8]=[CH:7][C:6]([N+:12]([O-:14])=[O:13])=[C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:15])[CH:10]=1)[C:24]([O:23][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:36])[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

Reactant 2

HCID 84754Dibenzyl malonate

HCID 603450Ethyl 5-chloro-2-nitrobenzoate

Product 1

HCID 576832443-Ethoxycarbonyl-4-nitrophenylmalonic acid dibenzyl ester

Procedure

The 5-chloro-2-nitrobenzoic acid ethyl ester (4.40 g) obtained in Example 9-4b) and malonic acid dibenzyl ester were subjected to reactions similar to those in Example 1-3a) to give the title compound (4.61 g).

Sources & evidence

ORD record: ord-de1bf31d52c442e9bea538eab4600227
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538140B2

Linked notes

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