Methyl 2-phenyl-2-propylpentanoate → 2-(4-Fluorophenyl)-2,5-dimethylhexanoic acid

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:18])([CH2:13][CH2:14][CH:15]([CH3:17])[CH3:16])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.C1(C(CCC)(CCC)C(OC)=O)C=CC=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:18])([CH2:13][CH2:14][CH:15]([CH3:16])[CH3:17])[C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 11658708Methyl 2-phenyl-2-propylpentanoate

HCID 68872679Methyl 2-(4-fluorophenyl)-2,5-dimethylhexanoate

Product 1

HCID 688699802-(4-Fluorophenyl)-2,5-dimethylhexanoic acid

Procedure

The title compound was prepared according to the procedure of Example 1C, substituting the compound of Example 22B for the compound of Example 1B. 1H NMR (300 MHz, CDCl3): δ 0.86 (t, J=6.43 Hz, 6 H) 1.05 (m, 2 H) 1.51 (m, 4 H) 1.96 (m, 2 H) 7.02 (m, 2 H) 7.34 (m, 2 H).

Sources & evidence

ORD record: ord-2a168cabdfa8437baeffe0a8050076b3
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538105B2

Reaction notes

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