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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 4949Generated: October 23, 2026

Hydrochloric Acid → Ethyl 2-(piperidin-4-yl)acetate

https://huagongshe.com/en/reaction/4949

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantEthyl pyridine-4-acetateHCID 736321—
CatalystPlatinum oxide (PtO)HCID 82844—
SolventEthanolHCID 702—
SolventHCID 178418361HCID 178418361—
ProductEthyl 2-(piperidin-4-yl)acetateHCID 2760465162.3%

Reaction Steps

16.5 g (0.1 mol) Ethyl 4-pyridylacetate, 8.4 mL (0.1 mol) 12N hydrochloric acid and 2.5 g platinum oxide were dissolved in absolute ethanol and hydrogenated at 40 psi hydrogen on a Parr shaker. After 1 hour, the contents of the vessel were filtered and concentrated in vacuo yielding 27.79 g of ethyl 4-piperidinylacetate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05242924
Source datasetuspto-grants-1993_09
ORD IDord-4bf57d14da074ba286dc99dcf47db4ab
Source noteuspto-grants-1993_09