HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 495Generated: October 23, 2026
4-(2-methyl-1H-imidazol-1-yl)aniline → 4-methyl-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one
https://huagongshe.com/en/reaction/495
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(2-methyl-1H-imidazol-1-yl)aniline | HCID 3157478 | — |
| Reactant | 8-Chloro-4-methyl-2-phenyl-3,4-dihydropyrido[3,2-F][1,4]oxazepin-5(2H)-one | HCID 59577825 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 2-(Dicyclohexylphosphino)biphenyl | HCID 2734216 | — |
| Catalyst | Palladium (II) acetate | HCID 4144353 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-methyl-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one | HCID 49820084 | 42.31% |
Reaction Steps
were placed in a microwave vial equipped with a stirring bar. The vial was capped and flushed with argon. DME (2 mL) was added via a syringe and the mixture was heated to 100°C in a microwave apparatus for 1h. The reaction mixture was filtered, the solvent was evaporated and the residue was purified by HPLC to give 53 mg (42 % yield) of the product as a solid.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-1df95b34548d48fe94a49234436e46e5 |
|---|
| Source note | 750 AstraZeneca ELN dataset |
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