Ethylene Glycol → 2-(4-Chloro-2-methoxyphenyl)acetic acid

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5](CC#N)=[C:4]([O:11][CH3:12])[CH:3]=1.[OH-:13].[K+].[CH2:15]([OH:18])[CH2:16]O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:16][C:15]([OH:18])=[O:13])=[C:4]([O:11][CH3:12])[CH:3]=1

Participants

Reactant 3

HCID 174Ethylene Glycol

HCID 14797Potassium Hydroxide

HCID 223275242-(4-Chloro-2-methoxyphenyl)acetonitrile

Product 1

HCID 146755682-(4-Chloro-2-methoxyphenyl)acetic acid

Procedure

141 g of 4-chloro-2-methoxyphenylacetonitrile are reacted with 83.2 g of potassium hydroxide in 280 ml of ethylene glycol. 148 g of solid are obtained (m.p.: 100° C.).

Sources & evidence

ORD record: ord-480af8e89db840cf98c26591f1e61ded
Source dataset: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06939888B2

Reaction notes

Loading…