Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 496Generated: October 25, 2026

4-(2-methyl-1H-imidazol-1-yl)aniline → 4-methyl-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

https://huagongshe.com/reaction/496

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(2-methyl-1H-imidazol-1-yl)anilineHCID 3157478—
Reactant8-Chloro-4-methyl-2-phenyl-3,4-dihydropyrido[3,2-F][1,4]oxazepin-5(2H)-oneHCID 59577825—
ReagentCesium carbonateHCID 10796—
Catalyst2-(Dicyclohexylphosphino)biphenylHCID 2734216—
CatalystPalladium (II) acetateHCID 4144353—
Solvent1,2-DimethoxyethaneHCID 8071—
Product4-methyl-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-oneHCID 4982008474.93%

Reaction Conditions

Temperature100 °C

Reaction Steps

Not continued.

Provenance & Evidence

Source dataset750 AstraZeneca ELN dataset
ORD IDord-b66bb670a88e49d4a4b3a67904494b50
Source note750 AstraZeneca ELN dataset